Binding/intercalation of drugs and peptides/proteins into lipid membranes...
Biomembranes, membrane ‘rafts’, lipids, and membrane proteins are entering into the forefront of biosciences. Use of monolayers has paved way to breakthroughs in the molecular mechanisms of action of phospholipases, lung surfactant, cellular signaling, antibiotic peptides, blood coagulation, and cell adhesion, just to name a few examples.
The Kibron DeltaPi and DeltaPi-4 can be readily operated as standard, high precision tensiometers. However, they can be operated as Langmuir-tensiometers and arethus ideal for the following applications:
- monitoring enzyme action on monolayers
- 2-D crystallization of proteins
- measuring specific interactions of drugs and peptides/proteins with lipid monolayers
- complex formation by nucleic acids (DNA, siRNA) and cationic lipids
