Delta-8

Delta-8 is a unique high throughput surface tension plate reader, for e.g. HTS screening of critical micelle concentration (CMC) values of surface active materials.

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Overview

Kibron Delta-8: high throughput critical micelle concentration

Kibron Delta-8 represents a true breakthrough, making high throughput screening possible in surface chemistry, from critical micelle concentration measurement to advanced drug discovery.

For pharmaceutical companies Delta-8 serves as the platform for Kibron PLDscreen, a unique assay predicting phospholipidosis with unprecedented accuracy, as well as for physicochemical profiling (QSAR) of compounds, providing key parameters such as Kaw, TSA, critical micelle concentration and surface pKa.

For chemical industries, including surfactant/detergent suppliers and users, Delta-8 represents a revolutionary platform for cost-efficient product optimization. High throughput screening of critical micelle concentration and surface tension can be made more than 100 times faster compared to conventional methods, with minimal sample consumption.


As high content screening of molecules has become a standard procedure within the industry, it has started to undergo rapid evolution also into the academic sector. HTS allows discovery driven research projects to be tackled on a totally new scale, generating data at unprecedented rate.

The high throughput of Delta-8 opens new exciting possibilities for surface chemistry R&D, allowing comprehensive and truly efficient physicochemical profiling.

In ADME/tox Kibron Delta-8 has already provided novel data and correlations (Study on fraction absorbed). However, this is just the tip of the iceberg. Kibron wants to explore new application areas for Delta-8 and looks actively for collaboration in the this field.

Specifications

Temperature range 18–30°C
Measurement volume 50 μl/well
Surface tension range 10-100 mN/m
Resolution 0.01 mN/m
Balance resolution 0.050 μgrams
Precision 0.2 mN/m
Method du Noüy-Padday
Measurement time (96-well plate) 3 minutes
Probe lifetime 100 plates
Cleaning of Dyneprobes DyneClean electric furnace
DyneClean lifetime 400 plates

 

DynePlate - 96-well plates

Dimensions 127.8 × 85.5 mm (standard footprint)
Volume per well 50 μl
Type Disposable

 

Software

Supported OS NT4.0 /2000/XP
Min. requirements PII266 MHz, 64 MB memory, CDROM-drive,
SVGA display, one free COM port, 25 MB disk
space
Communication RS-232

 

Physical dimensions

Weight 24 kg / 52,911 lbs.
Height 405 mm / 15,945 in.
Width 770 mm / 30,315 in.
Depth 380 mm / 14,961 in.

 

Power supply

Input 100 –120/200 –240 V, 47– 63 Hz.
Output 12 V DC, 10.8 A.
Power max. 120 W
CE-approved  

 

Safety standards

EMC-Directives

IEC61010-1:2001, EN55011:1998, EN61003-3-2:1995, EN61000-3-3:1995, EN61000-4-2:1995, EN61000-4-3:1996, EN61000-4-4:1996, EN1000-4-5:1996, EN61000-4-6:1996, N61000-4-11:1994

Accessories

DynePlates

  • Standard size 96-well plate made out of chemically resistant polypropylene.
  • For use in the Kibron Delta-8.
  • 15 microliter sample volume.
  • Disposable and resyclable.
  • Contamination free.

DyneClean

  • Cleaning furnace for automatic cleaning of probes in Delta-8.
  • Heats up to 1000C.
  • Clean eight probes simultaneously.
  • Avoid surfactant contamination.
  • For use up to 100 times.
 
 

DyneProbe

Chemically resistant. Made for good surface wettability. Du Noüy-Padday technique. Suitable probe for small sample volume.

 

How it works

Publications

Publications

We have compiled a list of assorted articles that each utilizes Kibron Delta-8 for their experiments.

Click here to see a complete list or select one of the subjects listed below:

Customer Tesimonials

"The Procter & Gamble Company provides branded products and services of superior quality and value that improve the lives of the world's consumers. In this business, investing in the right research methodology is important in driving the development of superior technology. P&G uses the Kibron Delta-8 high throughput screening device as an R&D tool for research methodology."

"The Centre for Materials Discovery focuses on the use of high throughput methods for the discovery of materials with entirely new properties or step-change improvements in performance. The Kibron Delta 8-is an invaluable module in a number of our workflows, particularly in programs directed towards the design of new functional surfactants."

Professor Andrew Cooper, Director of the Centre for Materials Discovery, University of Liverpool

Agfa wants to sustain its world leader position in graphics and healthcare applications. Therefore continuous improvements are required, not only in product portfolio but also in research methodology. In this context the use of the right R&D tools, such as the Kibron Delta-8 high throughput screening device, is highly recommended.

Dr. Guido Desie, Project Manager High Throughput Screening, Agfa-Graphics-R&D-HTS, AGFA-GEVAERT