Solid science - selected publications

Phospholipidosis

Vitovic et al.  Assessment of drug-lipid complex formation by a high throughput Langmuir balance and correlation to phospholipidosis. J. Medicinal Chemistry 51(6), 1842-1848 (2008).

Casartelli et al. Cationic amphiphilic drugs may induce phospholipidosis. Cell Biology and Toxicology 19, 161-176 (2003).

Reasor, M.J. and Kacew, S., "Drug-Induced Phospholipidosis: Are There Functional Consequences?". Society for Experimental Biology and Medicine (2001).

Membrane binding & permeation

K. Kiehm, M. Brewster, J. Peeters, and J.B. Dressman. Estimating intestinal permeability by surface activity profiling. In AAPS Annual Meeting and Exposition, Nashville, November 6-10, 2005.

K. Kiehm, M. Brewster, J. Peeters, and J.B. Dressman. Comparison of drug partitioning between octanol/water and the air/water interface.

Fischer et al., 4th International Conference on Drug Absorption, Edinburgh, June 13-15 (1997).

Gerebtzoff, G., Li Blatter, X., Frentzel, A. and Seelig, A. ”Halogenation of drugs enhances membrane binding and permeation” ChemBioChem 5, 676-684 (2004)

Blood-brain barrier permeation

Suomalainen, P., Johans, C., Söderlund, T., Kinnunen, P.K.J., J.Med.Chem. 47, 1783-1788 (2004).

Seelig, A., Gottschlich, R., Devant, R. M., ”A method to determine the ability of drugs to diffuse through the blood-brain barrier”. Proc. Natl. Acad. Sci. USA.  91, 68-72 (1994).

Fischer, H., Gottschlich, R., Seelig, A., ”Blood-Brain Barrier Permeation: Molecular Parameters Governing Passive Diffusion.” J. Membr. Biol. 165, 201-211 (1998).

Multidrug resistance

Seelig, A., and Gatlik-Landwojtowicz, E. ”Biophysical characterization of inhibitors of multidrug efflux transporters - their membrane and protein interactions.” Mini-Reviews in Medic. Chem. 5, 135-151 (2005).

Seelig, A. ”Screening for multidrug resistance”. Screening 4, 20-21 (2004).

Ferté, A., ”Analysis of the tangled relationships between P-glycoprotein-mediated multidrug resistance and the lipid phase of the cell membrane” Eur. J. Biochem. 267, 277-294 (2000).

Onishi, Y., Hirano, H., Nakata, K., Oosumi, K., Nagakura, M., Tarui S., Ishikawa, T., ”High-Speed Screening and Structure-Activity Relationship Analysis for the Substrate Specificity of P-Glycoprotein (ABCB1)” Chem-Bio Inf. J. 3, 175-193 (2003).

Seelig , ”A general pattern for substrate recognition by p-glycoprotein” Eur. J. Biochem. 251, 252-261 (1998).

Seelig, A., Landwojtowicz, E., ”Structure-activity relationship of P-glycoprotein substrates and modifiers.” Eur.J.Pharm.Sci. 12, 31-40 (2000).

Toxicity

Iwasawa et al. Studies in surface science and catalysis. 132, 435 (2001).