Strongly cationic compounds
are retained by the lipid
membrane, potentially
causing phospholipidosis.
Surface ionization constant (pKa)
The surface ionization constant (pKa) can be calculated and determined by measuring the adsorption isotherm of compounds at various pH values.
> Strongly cationic compounds will be retained by the lipid membrane, potentially causing phospholipidosis:
- Compound charge has been identified to represent one parameter in ADME/Tox research to predict the potential for causing phospholipidosis.
- With the high throughput Kibron Delta-8 the compound's surface ionization constant can be easily measured.