Surface ionization constant (pKa)
The surface ionization constant (pKa) can be calculated and determined by measuring the adsorption isotherm of compounds at various pH values.
> Strongly cationic compounds will be retained by the lipid membrane, potentially causing phospholipidosis:
- Compound charge has been identified to represent one parameter in ADME/Tox research to predict the potential for causing phospholipidosis.
- With the high throughput Kibron Delta-8 the compound's surface ionization constant can be easily measured.