Profiling with Kibron Delta-8 vs. common physicochemical methods
Comparison on two drugs
Method | Parameter | Hydroxynine | Phenyl butazone |
CNS+ | CNS- | ||
Common methods | MW | 447.8 | 308.4 |
LogP | 3.3 | 3.2 | |
TPS | 36 | 41 | |
Kibron Delta-8 | TSA | 78 | 146 |
Kaw | 10.000 | 1000 |
- >> In the above example only the compound true surface area (TSA) and the compound lipophilicity (Kaw) show a clear correlation to the CNS values.