The true surface area
and lipophilicity are key
compound properties in
ADME research.
Profiling with Kibron Delta-8 vs. common physicochemical methods
Comparison on two drugs
| Method | Parameter |
Hydroxynine
|
Phenyl butazone
|
| CNS+ | CNS- | ||
| |
|||
| Common methods |
MW | 447.8 | 308.4 |
| LogP |
3.3 | 3.2 | |
| TPS | 36 | 41 | |
| Kibron Delta-8 |
TSA | 78 | 146 |
| Kaw | 10.000 | 1000 |
- >> In the above example only the compound true surface area (TSA) and the compound lipophilicity (Kaw) show a clear correlation to the CNS values.