PLDscreen directly
measures the strength
of drug-phospholipid
complex formation.

PLDscreen principle

                                                             

The Kibron PLDscreen assesses phospholipidosis by measuring drug-phospholipid complex formation.

The binding affinity is reflected in changes in CMC for PLDnanosol and drug-PLDnanosol mixture, monitored by surface tension.

Hydrophobic effect and head group interactions (e.g. electrostatics) are the driving forces in the formation of micelles, allowing for detailed interpretation of data and the molecular mechanism(s) involved.

Unlike e.g. cell based and toxocogenomics assays PLDscreen does not give false positives or false negatives!